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SPYRE THERAPEUTICS INC (SYRE)

Institutional ownership, SEC filings and insider activity

Sector: Healthcare & Pharma · SEC CIK 0001636282 · EDGAR filings · Updated 2026-07-02

SPYRE THERAPEUTICS INC (SYRE) has reported institutional ownership of 95.2%, with 198 institutional managers holding positions valued at $4.16B per the latest 13F reporting period. SEC filings include an active non-reliance notice on previously issued financial statements (8-K Item 4.02), notice of delisting or failure to satisfy a continued listing rule (8-K Item 3.01), substantial-doubt (going concern) disclosure per the filings.

Institutional ownership
95.2%
Institutional managers
198
Reported 13F value
$4.16B
Insider activity
16 trans.
−$3.47M net selling
Data flags
3 active
from SEC filings

Latest updates

Institutional ownership overview

According to SEC 13F filings tracked by Sightfile, SPYRE THERAPEUTICS INC has 198 institutional holders and institutional ownership of 95.2%.

Insider activity

Insiders reported 16 transactions (0 buys, 14 sells) across 3 reporting insiders, with a net reported value of −$3.47M.

Data flags from SEC filings

Active non-reliance notice on previously issued financial statements (8-K Item 4.02), most recently filed 2024-11-18 (recurring since 2024-11-18) — source filing. The authoritative details are those stated in the filing itself.
Active notice of delisting or failure to satisfy a continued listing rule (8-K Item 3.01), most recently filed 2024-01-18 (recurring since 2022-07-19) — source filing. The authoritative details are those stated in the filing itself.
Active substantial-doubt (going concern) disclosure per the filings, most recently filed 2023-11-09 (recurring since 2022-03-08) — source filing. The authoritative details are those stated in the filing itself.

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See full history, cross-references and alerts on Sightfile
Sightfile provides information only — not investment advice, recommendations, or an assessment of any security. Data is derived from official public sources (SEC EDGAR and U.S. government agencies), may contain errors or delays, and should be verified against the source filing before relying on it.
Data sources: SEC EDGAR (filings, 13F, FTD), aggregated by Sightfile. Page updated 2026-07-02.